ABSTRACT
Trade name: Ethamolin (Cypros) Other common trade name: Ethanolamine oleate Indications: Bleeding esophageal varices Category: Sclerosing agent Half-life: N/A Clinically important, potentially hazardous interactions with: acitretin,
amobarbital, aprobarbital, butabarbital, disulfiram, insulin, mephobarbital, pentobarbital, phenobarbital, primidone, secobarbital, thiopental
Reactions
Skin Dermatitis
(2002): Bowling JC+, Contact Dermatitis 47(2), 116 (1995): Kock P, Contact Dermatitis 33, 273 (1994): Aranzabal A+, Contact Dermatitis 31, 121 (1994): Ortiz-Frutos FJ+, Contact Dermatitis 31, 193 (1994): Schnuch A, Contact Dermatitis 30, 243
Other Anaphylactoid reactions (<1%)
Injection-site necrosis
Trade name: Placidyl (Abbott) Other common trade names: Arvynol; Nostel Indications: Insomnia Category: Sedative-hypnotic Half-life: 10-20 hours Clinically important, potentially hazardous interactions with: antihistamines,
brompheniramine, buclizine, chlorpheniramine, clemastine, dexchlorpheniramine, meclizine, tripelennamine
Reactions
Skin Allergic reactions (sic)
Bullous eruption (from overdose) (1990): Yell R P, Am J Emerg Med 8, 246 (1980): Brodin MD+, J Cutan Pathol 7, 326 Diaphoresis Fixed eruption (1965): Auerbach R, Arch Dermatol 92, 184 Pruritus Purpura (1972): Jakobson ES, Ann Intern Med 77, 73 (fatal) Rash (sic) (1-10%) Urticaria
Other Acute intermittent porphyria
Death Dysgeusia (>10%) Facial numbness (sic) Hypersensitivity Paresthesias Pressure necrosis (1990): Chamberlain JM+, Am J Emerg Med 8, 467
Trade name: Trecator-SC (Wyeth) Other common trade names: Ethatyl; Etiocidan; Myobid-250; Tubermin Indications: Tuberculosis Category: Tuberculostatic Half-life: 2-3 hours
Reactions
Skin Acne
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford
(passim) (1965): Drug Ther Bull 3, 61 (1963): Lees AW, Am Rev Respir Dis 88, 347 Allergic reactions (sic) (1971): Med Lett 13, 55 (1%) Butterfly eruptions on the face (sic) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford
(passim) Eczema (sic) (chiefly involving the forehead) (1992): Breathnach SM+, Adverse Drug
Reactions and the Skin Blackwell, Oxford, 159 (passim) Edema of foot (1987): Schmutz JL+, Ann Dermatol Venereol (French) 114, 569 Exanthems (1969): Agrawal R, BMJ 4, 540 (1965): Carey VCI, Tuberde 46, 287 Ichthyosis (1972): Levantine A+, Br J Dermatol 86, 651 Lupus erythematosus (1973): Desmons MF, Bull Soc Fr Dermatol Syphiligr (French) 80, 168 Photosensitivity (1966): Baran R, Hôpital (French) 54, 445 (1966): Friedmann ME, Bull Soc Franc Dermatot Syphiligr (French) 73, 510 Purpura (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford
(passim) Rash (sic) (<1%) Seborrheic dermatitis (1972): Levantine A+, Br J Dermatol 86, 651 Urticaria (1-5%)
Hair Hair-alopecia (<1%)
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 159 (passim)
(1966): Baran R, Hôpital (French) 54, 445
Other Dysgeusia (1-10%) (metallic taste)
Gynecomastia (<1%) Headache Oral ulceration Sialorrhea Stomatitis (<1%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford
(passim) Stomatodynia
Xerostomia
Trade name: Zarontin (Parke-Davis) Other common trade names: Emeside; Ethymal; Petnidan; Pyknolepsinum; Simatin;
Zarondan Indications: Absence (petit mal) seizures Category: Succinimide anticonvulsant Half-life: 50-60 hours
Reactions
Skin Erythema multiforme (<1%)
(1966): Coursin DB, JAMA 198, 113 Exanthems (1-5%) (1991): Pelekanos J+, Epilepsia 32, 554 (1966): Weinstein AW+, Am J Dis Child 111, 63 (2.2%) Exfoliative dermatitis (<1%) Lupus erythematosus (>10%) (1996): Miyasaka N, Intern Med 35, 527 (1996): Takeda S+, Intern Med 35, 587 (1996): Wallace SJ, Drug Saf 15, 378 (1994): Riviello JJ+, J Epilepsy 7, 23 (1994): Yung RL+, Rheum Dis Clin North Am 20, 61 (1993): Ansell BM, Lupus 2, 193 (1993): Drory VE+, Clin Neuropharmacol 16, 19 (passim) (1985): Lovisetto P+, Recenti Prog Med (Italian) 76, 84 (1984): Koike K+, Rinsho Ketsueki 25, 1635 (1981): Grossman J+, Arthritis Rheum 24, 927 (1980): Condemi JJ, Geriatrics 35(3), 81 (1979): Tor J+, Med Clin (Barc) (Spanish) 73, 443 (1976): Singsen BH+, Pediatrics 57, 529 (1975): Teoh PC+, Arch Dis Child 50, 658 (morphea-like) (1973): Beernink DH+, J Pediatr 82, 113 (1970): Alter BP, J Pediatr 77, 1093 (1970): Dabbous IA+, J Pediatr 76, 617 (1968): Livingston S+, JAMA 203, 731 (1968): Monnet P+, Lyon Med (French) 220, 467 Periorbital edema
Pruritus Purpura (1967): Kontsouliers E, Lancet 2, 310 Rash (sic) (<1%) Raynaud’s phenomenon (1990): Rose CD+, Arthritis Rheum 33(Suppl) R23 (1975): Taaffe A+, Br Dent J 138, 172 (1966): Coursin DB, JAMA 198, 113 Side effects (sic) (3.4%) (1966): Weinstein AW+, Am J Dis Child 111, 63 Stevens-Johnson syndrome (>10%) (1975): Taaffe A+, Br Dent J 138, 172 Urticaria (1-5%) (1966): Weinstein AW+, Am J Dis Chiid 111, 63 (1%)
Hair Hair-alopecia
Hair-hirsutism
Other Acute intermittent porphyria
Gingival hyperplasia Headache Oral ulceration Tongue edema
Trade name: Peganone (Abbott) Other common trade name: Accenon Indications: Tonic-clonic (grand mal) seizures Category: Hydantoin anticonvulsant Half-life: 3-9 hours Clinically important, potentially hazardous interactions with: chloramphenicol,
cyclosporine, disulfiram, dopamine, imatinib, itraconazole
Reactions
Skin Bullous eruption
Fixed eruption
Lupus erythematosus Purpura (1967): Coleman WP, Med Clin North Am 51, 1073 Rash (sic)
Other Gingival hyperplasia
Pseudolymphoma (1958): Salzstein SL+, JAMA 167, 1618
Trade name: Didronel (Procter & Gamble) Other common trade names: Didronate; Difosfen; Dinol; Diphos; Osteum Indications: Paget’s disease, osteoporosis Category: Antihypercalcemic; Bone resorption inhibitor Half-life: 6 hours
Reactions
Skin Angioedema (<1%)
Exanthems Pruritus (1985): Holzmann H+, Hautarzt (German) 36, 326 Rash (sic) (<1%) Stevens-Johnson syndrome Toxic epidermal necrolysis (1995): Coakley G+, Br J Rheumatol 34, 798 Urticaria
Hair Hair-alopecia
Other Ageusia
Conjunctivitis (2003): Frauenfelder FW+, N Engl J Med 348, 1187 Dysgeusia (<1%) Glossitis Hypersensitivity (<1%)
Paresthesias Stomatitis
Trade name: Lodine (Wyeth) Other common trade names:Antilak; Ecridoxan; Edolan; Elderin; Lonine; Tedolan;
Utradol; Zedolac Indications: Pain Categoty: Nonsteroidal anti-inflammatory (NSAID) Half-life: 7 hours Clinically important, potentially hazardous interactions with: aspirin, methotrexate
Reactions
Skin Angioedema (<1%)
(1991): Astorga-Paulsen G+, Curr Med Res Opin 12, 401 Bullous eruption Dermatitis (sic) Diaphoresis Ecchymoses Edema Erythema multiforme (<1%) Exanthems (1998): Litt JZ, Beachwood, OH (personal case) (observation) (1997): Litt JZ, Beachwood, OH (personal case) (observation) (1990): Schattenkirchner M, Eur J Rheumatol Inflamm 10, 56 (1986): Lynch S+, Drugs 31, 288 (3%) Exfoliation (sic) Exfoliative dermatitis Facial edema (1991): Astorga-Paulsen G+, Curr Res Med Opin 12, 401 (1990): Freitas GG, Curr Med Res Opin 12, 255 Fixed eruption (1997): Blumenthal HL, Beachwood, OH (personal case) (observation) Flushing (1991): Astorga-Paulsen G+, Curr Med Res Opin 12, 401 Furunculosis (1987): Waltham-Weeks CD, Curr Med Res Opin 10, 540 Peripheral edema
(1990): Freitas GG, Curr Med Res Opin 12, 255 Photosensitivity (1987): Waltham-Weeks CD, Curr Med Res Opin 10, 540 Pigmentation Pruritus (1-10%) (1998): Litt JZ, Beachwood, OH (personal case) (observation) (1991): Astorga-Paulsen G+, Curr Res Med Opin 12, 401 (1991): Balfour JA+, Drugs 42, 274 (1991): Bianchi-Porro G+, J Intern Med 229, 5 (1991): Med Lett Drug Ther 33, 79 (1991): Karbowski A, Curr Med Res Opin 12, 309 (1990): Schattenkirchner M, Eur J Rheumatol Inflamm 10, 56 (1989): Ciocci A, Curr Med Res Opin 11, 471 Purpura Rash (sic) (>10%) (1991): Anon, Med Lett Drug Ther 33, 79 (1991): Astorga-Paulsen G+, Curr Med Res Opin 12, 401 (1991): Balfour JA+, Drugs 42, 274 (1989): Ciocci A, Curr Med Res Opin 11, 471 (1989): Williams PI+, Curr Med Res Opin Stevens-Johnson syndrome (<1%) Toxic epidermal necrolysis (<1%) Urticaria (<1%) (2000): Mitchell D, Thomasville, GA (from Internet) (observation) (1996): Thaler D, Monona, WI (personal case) (pressure) (observation) Vasculitis (1996): Lie JT+, J Rheumatol 23, 183 (hypersensitivity) (1989): Willemin B+, Ann Méd Int (French) 140, 529 Vesiculobullous eruption
Hair Hair-alopecia
Other Gingival ulceration
Glossitis Gynecomastia Parageusia Paresthesias Sialorrhea Stomatitis Tinnitus Ulcerative stomatitis Xerostomia
