Botulinum toxin (BTX) has taken the practice of medicine by surprise and with a furor. Rarely can one find such a simple protein that in its natural form is so deadly, but by purification and minor extraction techniques can be utilized for therapeutic purposes by both physicians and surgeons. The application of BTX in neuromuscular disorders has provided fortuitous relief for many tormented with incurable diseases, affording them an encouraging respite from their devastating afflictions. The countless possibilities for the use of BTX in medicine are on the verge of being discovered. From neurologists and physiatrists, to ophthalmologists and otolaryngologists, and now for gastroenterologists and even the cosmetic surgeons, BTX has proven to be a powerful adjunctive modality for a multitude of disorders.