ABSTRACT
Type 2 diabetes mellitus has moved from the status of a disease which
This change is requiring physicians who treat children to learn about the
diagnosis, treatment, and prevention of this ‘new disease’. It is now
important to recognize not only the microvascular complications of
insulin-deficient type 1 diabetes but also to address and prevent the
macrovascular complications such as arteriosclerotic, cardiovascular, and
peripheral vascular occlusive disorders associated with the insulin resis-
tant syndrome (IRS) and type 2 diabetes. One must also consider the
therapy of the other disorders frequently associated with these condi-
tions, including hypertension, obesity, dyslipidemia, ovarian hyperan-
drogenemia, and nonalcoholic steatohepatititis (NASH). This discussion
will deal only with the management of the hyperglycemia; therapy of
co-morbid conditions will be mentioned only briefly, as it is beyond the
scope of this chapter.
