ABSTRACT

Cutaneous manifestations ● Thick, yellow-brown, parchment-like hyperkeratosis involving palms and soles, well

demarcated by an erythematous ring (non-transgrediens form resembling Unna-Thost disease) (Figures 7.1-7.3)

● Decreased resistance to physical trauma resulting in blisters and erosions ● Hyperhidrosis

Course

There is a stable course, with difficulty in walking and social discomfort.