ABSTRACT
Overactive bladder (OAB) continues to plague millions of patients. Existing management of this serious malady involves pharmacological manipulation of the micturition reflex. The reflex comprises two arms, the afferent nerve signaling by C fibers and A fibers, and the efferent branch constituted by sympathetic and parasympathetic nerves. One of the predominant treatment modalities targets the cholinergic transmission in the efferent branch of the voiding reflex with the use of anticholinergic drugs.1 Drugs acting at the afferent branch of the micturition reflex such as vanilloids have been only partly successful in the clinic so far.2,3 Perhaps better analogs and improved drug delivery will be able to change that scenario.
