A large number of cutaneous and systemic disorders may be associated with eyelid lesions. In many instances the eyelid findings are quite specific for a particular disorder, at other times they may be rather non-specific. These ocular findings in combination with other cutaneous and systemic abnormalities frequently allow the clinician to make the correct diagnosis. Localized unilateral eyelid lesions most commonly represent benign or malignant neoplasms, infections, or inflammations. Bilateral lesions more frequently represent disseminated systemic conditions such as collagen vascular diseases, metabolic disorders, vesico-bullous diseases, dermatoses, and hypersensitivity disorders.