ABSTRACT

Ready-to-use solution dosage forms comprise the largest percentage of sterile dosage forms in the marketplace. The solution formulation must be resistant both to physical and chemical degradation. Drugs in solution are subject to several major mechanisms of degradation-hydrolytic, oxidative, photolytic, and, for proteins, covalent and noncovalent aggregations, deamidation, cleavages, oxidation, and surface denaturation reactions.