ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to a group of therapeutic agents that are
frequently prescribed because of their analgesic and antipyretic properties. Many NSAIDs
are also available without a prescription and are generally considered safe. However, because a
large population of patients is exposed to these drugs, it is not surprising that a relatively large
number of adverse effects have been reported. The extremeworldwide use has led to an extensive
literature on the incidence and types of major and minor adverse effects. Although the most
frequent adverse effects associated with the use of NSAIDs clearly occur in the gastrointestinal
tract, and also cardiovascular safety has become an issue of increasing concern, other target
organs including the liver, have been identified. Comprehensive reviews are available that
summarize the risk and the clinical manifestations of NSAID-related hepatic disorders (1-19).
