This chapter is comprised of three major sections. The ﬁrst section examines the factors that
alter liver metabolism and how this can affect efﬁcacy and toxicity from anticancer drugs. The
second section will review liver toxicity in hematopoietic stem cell transplantation; this topic
warrants its own section, since several of the conditioning regimens for stem cell trans-
plantation have a high incidence of liver toxicity and a high case-fatality rate. The ﬁnal
section is the more traditional review of hepatotoxicity listed for individual anticancer drugs.
HEPATIC METABOLISM OF ANTICANCER DRUGS