ABSTRACT
Introduction One can consider two approaches to the diagnosis and management of unexplained infertility. The first is strictly scientific, with a quest for and exclusion of each known cause of infertility before the label “unexplained infertility” can be given. The second approach is a pragmatic one based upon a management-oriented policy, whereby treatment is commenced after the common obstacles to fertility have been excluded.1 The treatment of unexplained infertility essentially aims to boost fertility, usually by a combination of superovulation and close apposition of sperm and egg(s). Sometimes the use of assisted conception techniques provides clues to the underlying diagnosis, for example if there are problems with fertilization that can only be detected during in vitro fertilization (IVF) therapy.
