ABSTRACT
Clinical Efficacy for Skin Antiaging Twelve-Week Randomized Placebo-Controlled Antiaging Study The clinical signs of photoaging are a persistent concern for many patients. Intrinsic factors and cumulative exposure to extrinsic factors such as UV lead to the development of skin laxity, fine lines, wrinkles, hyperpigmentation, and sallowness. A 12-week, double-blind, placebo-controlled clinical study was performed to evaluate the efficacy and tolerability of a topical composition containing the bimineral complex in reducing the clinical signs of facial photoaging, including the delicate periorbital area (65). The study consisted of three treatment groups: (i) placebo moisturizer, (ii) bimineral complex moisturizer, and (iii) bimineral complex moisturizer with activator. The study population consisted of 94 healthy women, aged 40 to 65, with Fitzpatrick Skin Type of II to IV and mild to moderate photoaging. Subjects applied the bimineral complex twice daily, in the morning and evening. Evaluations included clinical grading of safety and efficacy parameters, high-resolution digital imaging, and subject self-assessments. All measures were taken at baseline and weeks 2, 4, 8, and 12.
