ABSTRACT
Trade names: Bio-Active Selenium (Solaray); Exsel Shampoo; Head & Shoulders Intensive Treatment Dandruff Shampoo (Procter & Gamble); Selenate; Selenite; selenium dioxide; selenium sulfide; selenocysteine; SelenoMax (Source Naturals); selenomethionine; Selsun Blue (Chattem); Selsun Shampoo (Chattem); Vpak51 Indications: Anticancer (stomach, colorectal, lung, prostate), arthritis, asthma, heart disease, HIV inhibitor. Treatment of dandruff, fungal infections (tinea versicolor), and seborrhea Category: Antioxidant; Trace element Half-life: 12-41 hours; Selenomethionine: 252 days, Selinite: 102 days Clinically important, potentially hazardous interactions with: cholesterol-lowering drugs, cisplatin, clozapine, dimercaprol, niacin, oral corticosteroids, simvastatin
Note: Selenium is an essential component of glutathione peroxidase. Inadequate concentrations of dietry selenium account, in part, for Keshan disease (a fatal cardiomyopathy)
Skin Adverse effects
(1994): Yang G+, J Trace Elem Electrolytes Health Dis 8(3-4), 159 (chronic exposure)
(1989): Stacchini A+, J Trace Elem Electrolytes Health Dis 3(4), 193
Allergic reactions Carcinoma
(2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic exposure)
(2000): Vinceti M+, J Clin Epidemiol 53(10), 1062 (chronic exposure)
Dermatitis (2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic
exposure) Diaphoresis Erythema chronicum persistans
(2003): Smith S, Louisville, KY (from Internet) (observation) Infections Lupus erythematosus (from deficiency) Melanoma
(1998): Vinceti M+, Cancer Epidemiol Biomarkers Prev 7(10), 853 (chronic exposure)
Photosensitivity Pruritus Rash Scleroderma (deficiency)
Hair Alopecia
(2001): Vinceti M+, Rev Environ Health 16(4), 233 (chronic exposure)
(1996): Whanger P+, Ann Clin Lab Sci 26(2), 99 (chronic exposure)
Brittle hair (1994): Yang G+, J Trace Elem Electrolytes Health Dis 8(3-4), 159
(chronic exposure) Hair – changes
(1999): Barceloux DG, J Toxicol Clin Toxicol 37(2), 145 (chronic exposure)
(1997): Hathcock JN, Am J Clinical Nutrition 66, 427 Hair pigmentation
Nails Brittle nails
