ABSTRACT
Synonym: Ursodiol Trade names: Destolit (Norgine); Urso (Forte) (Axcan) Indications: The dissolution of radiolucent (i.e. non-radio opaque) cholesterol gallstones in patients with a functioning gallbladder, primary biliary cirrhosis, biliary calculus. Category: Cholesterol antagonist Half-life: 3.5 – 5.8 days Clinically important, potentially hazardous interactions with: aluminium hydroxide, antacids, charcoal, cholestyramine, colestimide, colestipol, cyclosporine, cytochrome P4503A substrates, dapsone, estrogenic hormones, nitrendipine, oral contraceptives
