ABSTRACT
Synonym: adrenaline Trade names: Adrenalin (Monarch); Adrenaline; Ana-Guard; AsthmaHaler; Bronitin; Bronkaid; Epi E-Z Pen; Epifrin; Epipen (DEY); Eppy; Eppystabil; Isopto-Epinal; MedihalerEpi; Primatene; Primatene Mist; S-2; Simplene Indications: Cardiac arrest, hay fever, asthma, anaphylaxis Category: Catecholamine; Sympathomimetic Half-life: N/A Duration of action: 1-4 hours Clinically important, potentially hazardous interactions with: albuterol, alpha-blockers, amitriptyline, amoxapine, atenolol, beta-blockers, carteolol, chlorpromazine, clomipramine, cocaine, desipramine, doxepin, ephedra, ergotamine, furazolidone, halothane, imipramine, insulin detemir, MAO inhibitors, metoprolol, nadolol, nortriptyline, oxprenolol, penbutolol, phenelzine, phenoxybenzamine, phenylephrine, pindolol, prazosin, propranolol, protriptyline, sympathomimetics, terbutaline, thioridazine, timolol, tranylcypromine, tricyclic antidepressants, trimipramine, vasopressors
Skin Dermatitis
(1993): Gaspari AA, Contact Dermatitis 28, 35 (1980): Romaguera C+, Contact Dermatitis 6, 364
Diaphoresis (1-10%) Exanthems Fixed eruption Necrosis
(1984): Antrum RM+, Br J Clin Pract 38, 191 Pallor (<1%) Pemphigus (cicatricial)
(1981): Vadot E+, Bull Soc Ophtalmol Fr (French) 81, 693 Urticaria
Hair Alopecia
Mucosal Xerostomia (<1%)
Cardiovascular Chest pain
(2006): Putland M+, Ann Emerg Med 47(6), 559 Flushing (1-10%) Hypotension
(2006): Putland M+, Ann Emerg Med 47(6), 559 (2006): Yang JJ+, J Pharm Pharm Sci 9(2), 190
Myocardial infarction (2006): Davidsen JR+, Ugeskr Laeger 168(11), 1137 (2005): Arfi AM+, Indian Heart J 57(3), 261
QT prolongation (2004): Abriel H+, Swiss Med Wkly 134(47-48), 685
Tachycardia (2006): Putland M+, Ann Emerg Med 47(6), 559
Central Nervous System Headache Trembling (1-10%)
Local Injection-site necrosis Injection-site pain Injection-site urticaria
