Over the past decade, the pressures for museums to respond to changes in the external environment have accelerated. Museum leaders have launched new initiatives, created collaborative partnerships, experimented with innovative methods for generating new revenue, and undertaken strategic planning to refine institutional viability. While these are significant, essential, and accepted efforts of moving an institution forward, organizational structure and culture often remain unexamined as key elements of institutional change and long-term viability. It is time that these critical elements of museum operations move up the priority list for examination and adjustment, in order to build more resilient institutions that work and thrive in the twenty-first century.