In this chapter we are going to rebut the last of the readings of the microphysicalist’s thesis: micro-causation. Micro-causation is the thesis that all macro-causal relations occur in virtue of micro-causal relations. The causal relations among compound systems are entirely derivative of those of their parts. This thesis should not be conﬂated with a thesis that contrasts causal relations among micro-based properties of systems with those of the correlated macro-properties of the same systems. Micro-causation, as we will discuss it, concerns the question whether parts as opposed to wholes are the real causal agents. It does not concern the relation of two properties of the same system.