ABSTRACT
Experiments are reported which demonstrate the possibility, in the rat, of restoration of cognitive function by neural transplants made after damage to either diffuse (cholinergic) or point-to-point (intra-hippocampal) forebrain systems; but the transplant must be appropriate to the damage being repaired. Since the different types of brain damage studied provide partial analogues of human alcoholic dementia, Alzheimer’s disease and heart attack, these results are encouraging with regard to the eventual application of neural transplant surgery to the treatment of cognitive deficits in humans.
