ABSTRACT

Over the past half century, the field of human genetics has evolved from a single-gene to a multifactorial approach, spawning valuable technologies along the way. In the 1950s and 1960s, researchers matched human genes to specific health conditions, with the help of families in which an abnormal chromosome tracked with the disease. In the 1970s, recombinant DNA technology gave microbes human genes, which produced protein-based drugs. In the 1980s, sequencing the human genome was an idea; in the 1990s, it became reality. Since then, we have been seeking meaning in the data.