This conceptual chapter seeks to answer the research question: What are the determinants of internationalization in small knowledge-intensive firms (SKIFs)? It does so by establishing the meaning of the term ‘small knowledgeintensive firm’, by synthesizing literature from the small firm and knowledgeintensive firm literatures, and then subsequently marrying this definition with internationalization literature to yield a conceptual framework involving such key influences on internationalization as firm size, knowledge-intensity, the entrepreneur and environment. In each of these aspects, network relationships are seen to be influential. Implications of this discussion include the importance for SKIFs to prioritize and nurture network relationships, while seeking to strike a balance between strategy-making and responding opportunistically to new possibilities that emerge through these relationships.