ABSTRACT
In recent years the success of genomics has provided the impetus to explore and understand the molecular events that happen within the cell. The genome provides the information to manufacture a protein, but it provides none of the information on the activity or function of that protein once it has been synthesized by the cell. Post-translational modifications and changes in the intracellular levels of cofactors can significantly alter a protein’s activity, which is not easy to predict from the information provided by the genome. As a result there has been a collective refocusing upon the proteome and the methods that can be employed to isolate and identify key proteins.
