Two approaches were initially developed for DNA sequencing, which were the chemical method developed by Allan Maxam and Walter Gilbert and the enzymatic method, often referred to as the dideoxy chain termination method, developed by Fredrick Sanger and colleagues. Walter Gilbert and Fredrick Sanger received the Nobel Prize in Chemistry in 1980 “for their contributions concerning the determination of base sequences in nucleic acids”. The Sanger strategy is still used today in all sequencing protocols from small-scale sequencing you might do in your laboratory to the high-throughput genome sequencing.