The meaning of ‘kismet’, as originating in Turkish, is ‘fate’; ‘karma’ means in Sanskrit deliberate action, and in Vedic religions, such as Hinduism, it refers to the influence of deeds on incarnations. In line with the repeated warnings against human hubris, the continuous catastrophic dangers posed to our species by ‘fate’ need reemphasis. Humankind is not a natural agency, as is a person; nor is it institutionalized agencies, such as governments, corporations, families and states. Rather, it is a self-constituting agency in the making which at present is a conflictive composite. There are some beginnings of humanity moving toward becoming an operating agency, though with the speed of a lame snail. But there are two barriers which at present are unsurmountable. Dangers posed by resurrecting tribalism are widely discussed. However, what is widely ignored is its becoming deadlier thanks to science and technology; and because it prevents essential global coping with the fateful challenges posed by neogenesis technologies.