In this chapter, we explain what the Fourth Industrial Revolution means for human work. We introduce Kasparov’s Law, which tells us that superior performance does not necessarily require human genius nor superior machines; rather, it can be achieved through better processes using ordinary people and machines. Next, we explain Moravec’s Paradox to illustrate the symbiotic, mutually dependent relationship between man and machine. In contrast to the promise of combining the best of man and machine, we look at the peril of creating superintelligent machines. We discuss the control problem to underscore the gravity of what’s at stake in managing AI. We conclude by introducing the form of enterprise that leverages the collaboration between man and machine to achieve “superintelligence”—the Humachine.