This chapter presents ideas about supporting students’ intrinsic motivation and interest by focusing on what makes curricular content and learning activities interesting. The chapter begins with an overview of theory and research on interest, including a section on how interest develops. Concepts such as individual and situational interest are explored. Specific suggestions for supporting students’ interest in learning are presented. Next, ways in which teachers might enhance subject matter and learning activities are discussed, including use of curiosity and imagination. The chapter ends with a presentation of large-scale interventions designed to enhance students’ motivation to learn by connecting instruction with students’ existing interests and intrinsic motivation.