The agenda of issues involving Latin America has often required international attention and has led to several efforts at regime building. This chapter analyzes selected regimes, involving different institutional forms of governance, that are of particular relevance to Latin American international relations. It addresses regimes related to the Panama Canal, Mexican-United States riverine problems, the body of arms control treaties, the Antarctic Treaty, the law of the sea, and the North-South-oriented New International Economic Order. A series of international arms control agreements were negotiated in the 1960s and 1970s under the auspices of the United Nations. The Cuban missile crisis of 1962 supported fears that nuclear weapons would serve as a destabilizing element in Latin American international politics and gave great impetus to the establishment of a Latin American nuclear-free zone. The origins of the New International Economic Order may be traced to the first United Nations Conference on Trade and Development held in Geneva in 1961.