ABSTRACT
Roland Stockera,b, Andrew C. Terentisa, Joanne M. Upstona, and Leonard Kritharidesb,c
The role of lipoprotein oxidation, and particularly that of low density lipoprotein (LDL), in atherogenesis has been the subject of intense investigation. Major reviews of LDL oxidation have been published (see, e.g., Refs. 1-6). The aim of this article is to review randomized controlled studies investigating the clinical use of vitamin E supplements to prevent or treat coronary heart disease (CHD), and discuss the scientific basis for a role of vitamin E in the inhibition of lipoprotein lipid oxidation in the vessel wall.
