ABSTRACT
Some patients with lung, appear to have an extraordinary ability to synthesise polypeptides, which often give rise to para-neoplastic or endocrine syndromes. Many of the patients also have a greater weight loss than might otherwise have been expected, and about 10 % show a degree of anaemia. Nephropathy, leading to the nephrotic syndrome or renal impairment, encephalopathy, etc. may be caused by tumour anti-bodies, producing several types of auto-immune disease. Hypertrophic-pulmonary-osteoarthropathy was described by Pierre Marie in France in 1890 and by Bamberger in Germany in the same year, and in those countries is so eponymously known. Isotope bone scans may be used to demonstrate the condition, and in several cases these are more sensitive than plain radiographs.
