ABSTRACT
In 1909 Robert Knox published two cases, one a sarcoma of the chest wall, and the other pneumonia in a patient aged 20 which was very slow to clear. Adami and Nicholls and Kaufman, noted that lung tumours may cavitate and may arise either within a large bronchus or peripherally within a lobe. In the case of rapidly growing malignant tumours, the edges are not sharp but frayed, yet still distinguishable from the surrounding pneumonic shadow'. Most of the parenchymal tumours were adenocarcinomas, with an extraordinarily latent progress, pain of an indefinable but persistent nature and loss of weight without apparent cause. As lung tumours have a dual blood supply, from both pulmonary and bronchial vessels, they might be expected to show contrast enhancement.
