Mindfulness- and compassion-oriented integrative psychotherapy (MCIP) is a process-based therapy, which is based on scientific research into processes of change in psychotherapy. The chapter presents a new model, the integrative model of processes of change, that describes the processes of change that are related to different dimensions of human experience: interpersonal, cognitive, affective, physiological, behavioural, spiritual, and systemic/contextual. In the model mindfulness and compassion are presented as meta-processes of change that enhance all other described processes. The authors review the psychotherapy research studies related to each process of change. They explain how processes of change can be enhanced in the process of MCIP. The model of integrative processes of change helps therapists to track the client’s experience from moment-to-moment and encourage the relevant processes of change.