This chapter demonstrates an understanding of determinants, performance indicators, and impacts of entrepreneurship in Organization for Economic Co-operation and Development (OECD) economies. It analyzes the variation in the patterns of entrepreneurship across OECD economies, and demonstrates an understanding of various forms of entrepreneurial financing in OECD economies. The OECD is also strengthening partnership with key nonmember economies such as Brazil, China, India, Indonesia, Russia, and South Africa. The chapter also discusses the economic and political reforms undertaken by newly joined OECD members in a number of areas such as combating corruption, enhancement of corporate governance, and intellectual property rights (IPR) protection. Among OECD economies, Luxembourg and Switzerland have formulated favorable tax policy to stimulate entrepreneurship. Compared to less developed economies, OECD economies are characterized by a greater availability and easier access to financial resources for potential entrepreneur.