This chapter discusses S. Freud's point of view and shows that he considers that such patients must somewhere have the capacity to be analysed or he would not devote eighteen pages in The Ego and the Id to the phenomenon. It explores the need to attend to these patients' inner world of object relation and most particularly to the anxieties that underly their relationships. In Freud's remarks on the difficulties of the negative therapeutic reaction he has a footnote which in the connection is extremely interesting. The negative therapeutic reaction is generally understood as a condition which ultimately precludes analysis and makes it impossible; the phrase is constantly used as meaning unanalysable. Freud's remarks on the point are almost all in The Ego and the Id, the last eighteen pages of which deal with the problem of the unconscious sense of guilt.