Chapters 5 to 8 have a comparable structure because they describe the four prototypical designs. We take up the framework that is presented in Chapter 1 and one chapter is devoted to a detailed consideration of each of the designs (withdrawal/reversal, multiple-baseline, alternating-treatments, and changing-criterion designs). The first section of each chapter describes the rationale and basic structure of each design. Features that a design must incorporate in order to meet evidence standards are reviewed, and threats to internal validity and strategies for addressing them are discussed. The common types and variants of the prototypical design are described, along with their advantages and disadvantages. Illustrative cases from the neurorehabilitation literature are provided for each of the chapters.