ABSTRACT
There is no greater area of ethical concern for government and the general public than clinical research demonstrating patient safety and autonomy. A potential proceeding benefit to society can be the direct result of the study but with careful regimentation. The Office of Human Research Protection was established in 1991 to oversee ethical aspects of human subject research and resulted in the formation of Institutional Review Board (IRB). Central to the charge of IRBs was to maintain the principles put forth in the Belmont Report. Respect for persons requires that research subjects be treated as autonomous individuals capable of deliberation about personal goals. The American Medical Association (AMA) recognizes and supports the need for responsible animal use in biomedical research in the following statement: Researchers should include in their protocols a commitment to ethical principles that promote high standards of care and humane treatment of all animals used in research.
