This chapter explores the logic of research situations and the preference structures of scientists in the production of knowledge from an economic standpoint. One advantage of economics is that systematic conceptions of economic activity under typical or perhaps even normal everyday circumstances have been created. Replication failure will be considered as an economic phenomenon with an emphasis on the consequences of time and resource constraints that may lead to replication problems. Replication failure has become a problem in the economics profession. An economic analysis of replication failure in the economics profession may be extended by analogy to other sciences. For the sciences other than economics, there is a growing literature on the nature of replication and the associated problem of replication failure.