ABSTRACT
Sympathomimetics are a diverse group of drugs that have adrenergic properties. This chapter focused on two main classes of drugs: (1) derivatives of the natural product ephedrine that work primarily in the periphery and (2) the centrally acting stimulants. The ephedrine derivatives are used to alleviate cold symptoms. Their adrenergic activity can be pronounced, but they do not clearly show ergogenic properties. Their approved use during competition continues to generate debate. The centrally acting stimulants are powerful drugs that have abuse potential. They are illegal without a prescription and can cause significant and dangerous side effects when an individual is exercising. However, some of these drugs are useful in treating Attention Deficit/Hyperactivity Disorder. This somewhat paradoxical use of these drugs has helped provide researchers with additional tools for studying how the brain works. Exercise exerts effects in areas of the brain that are also targets for these stimulants. Regular exercise is encouraged as a helpful supplement to drug therapy for Attention Deficit/Hyperactivity Disorder.
