ABSTRACT
It is difficult to determine exactly how common drug interactions are. it is known that some of the early studies on the frequency of drug interactions looked at lists of drugs without appreciating that some of the potential interactions might not be clinically relevant (Preston, 2020). Most of the later studies have avoided this error by looking at only potentially clinically important interactions, and incidences of up to 8.8% have been reported (Preston, 2020). Even so, not all of these studies took into account the distinction that must be made between the incidence of potential interactions and the incidence of those where clinical problems actually arise. This chapter will cover who is at risk, pharmacokinetic interactions, and how to minimise the risk of drug interactions.
