This chapter focuses on the issue of autonomy within the context of environmental interdependencies by analyzing the relationship between the educational concept of “institutional autonomy” and private support. According to E. D. Duryea, the concept of institutional autonomy has its origin in 15th- and 16th-century England where the concept of corporate autonomy was first conceived. The concept of institutional autonomy must also incorporate the concept of professional autonomy that has developed in higher education, particularly at research universities. A number of educational scholars have commented on the growing external pressures to which America’s institutions of higher education have been subjected. The literature of higher education governance emphasizes that institutional autonomy of higher educational institutions has evolved beyond the concept of corporate autonomy. The chapter concludes that in order to be effective, charitable organizations must maintain a relatively high degree of autonomy so that they might determine and pursue their own goals.