Death has often been thought of as the final outcome of life, and many fear death. Even more people suffer from loss of loved ones and the grief that follows. This chapter focuses on the big issues of our relationship with death and what may be beyond death. We explore research regarding fear of death and dying and present the terror management theory that informs many therapeutic approaches for death anxiety. We explore strategies to cope with the death of a loved one and the grief that comes with it. We also take a quick look at recent research in the mind-body realm focused on the impact and implications of human near-death experiences. Real-life examples of the impact of death anxiety, the struggle of grieving, and additional extraordinary experiences are also presented.