This essay opens the book by inviting the reader to the conceptual re-framing of social work in a glocalised world, reshaped by economic, ecological, and social sustainability challenges in a post-anthropocentric perspective. It argues for a wor(l)dly reorientation towards, and practices that include, human interaction with the environment, life forms, and the relationship to objects and things and demonstrates how post-anthropocentric, post-human, and materialist philosophies reshape social work in the paradigmatic shift towards glocalisation.