This chapter argues that shifts in the spatial location of the demand for labor partially determines the mobility experience of workers. An empirical study of shift in employment subcenters in Mexico City Metropolitan Zone (MCMZ) between 1999 and 2019 is presented. By conducting an analysis of employment magnitude and density, the chapter identifies existing employment subcenters, assesses the economic specialization and the type of jobs available in each subcenter, and evaluates whether MCMZ tends toward a polycentric or a monocentric urban structure. The study shows that, despite MCMZ generating more employment subcenters, jobs are concentrating in space around the central and western areas of the metropolitan region.