H. Lundbeck & Co and Novo Nordisk are global biopharmaceutical giants based in Denmark. They are world leaders in their markets: disorders of the brain and central nervous system for Lundbeck, and diabetes and serious chronic diseases for Novo Nordisk. This chapters looks at the founders and scientists who built these companies through invention, innovation, marketing, mergers, and acquisitions. The industrial foundations they have spun off are among the largest on the planet and the research and educational endeavors they fund have improved the lives of millions. This chapter includes a head-to-head comparison of H. Lundbeck & Co and Novo Nordisk in four areas: Business, philanthropy, personal lives of the founders, and legacy. And it points out where each company illustrates the distinctives of the tandem hybrid social enterprise and offers takeaways for entrepreneurs and social entrepreneurs.