This chapter is a doctrinal analysis of socio-economic rights guaranteed in Africa’s regional human rights instruments. It first contextualises the currents that led to the establishment of the regional human rights regime, noting that Africa was a late entrant relative to other regions. Using the African Charter and other regional instruments as templates and deploying regional and comparative jurisprudence, the chapter examines the core socio-economic rights, including education, health, and work, and housing. It notes the unique contributions that these instruments make to the corpus of international human rights law, such as the legal recognition of all dimensions of rights. The chapter particularly notes the unique contributions of regional mechanisms to the progressive development of the corpus juris of socio-economic rights. Although challenges remain in terms of implementation, the chapter concludes that the emergent norms have guided states in understanding their treaty obligations, besides national and sub-regional judicial bodies that have deployed them to advance justice within their jurisdictions.