ABSTRACT
Any deviation from normal maturation pattern identied by FC, although not specic, may be associated with dysgranulopoiesis and is helpful in establishing the diagnosis of MDS. All ow cytometric features may be present on a subset of cells or involve the entire population. Single antigenic abnormalities are less specic for MDS than accumulation of several abnormalities. e intensity of aberrant expression is also variable but oen correlates with the degree of myelodysplasia. Low grade MDS tends to have less obvious changes, whereas high grade MDS (MDS with excess blasts; MDS-EB) shows more pronounced changes.
