ABSTRACT

Cerebellar abnormalities are part of the complex pathophysiology of schizophrenia, in which neural information processing streams and signaling are not properly synchronized. Structural and functional disruptions of interareal neural communication are linked to a disrupted pacemaker function of the cerebellum. The absence of functional integrity of the affective and cognitive brain circuits provides a neurobiological foundation for mental suffering. Restoring cerebellar function through neuromodulation holds future promise in mitigating symptoms in schizophrenia.