ABSTRACT
To date, the development of effective treatments for major psychiatric disorders has far exceeded our understanding of the neuropathophysiology underlying their symptomatic expression. Nevertheless, it is a firmly held tenet of modem medicine that a clear understanding of a disease's physiological mediation will result in the most rapid advances in treatment. It is for this reason that we and several colleagues at a number of universities have been studying brain function in obsessive-compulsive disorder (OCD) and related conditions for many years.
