This chapter describes the neoliberal reforms in Ghana in the last three decades and their overall development outcomes in relation to economic growth and improvement in the wellbeing of the subaltern classes. It argues that despite the impressive economic growth during the era of neoliberalism, the wellbeing of the subaltern classes has not witnessed a corresponding improvement. There were elite-led acts of resistance against neoliberalism and acts of resistance triggered by non-material grievances led by the subalterns. The chapter focuses on the types of resistance because they seem to define the context of resistance politics in Ghana. The 'Kume Preko' demonstration on 11 May 1995 in Accra, the national capital of Ghana, is, perhaps, the most momentous and massive resistance to neoliberalism in Ghana. A version of this demonstration, dubbed 'Sieme preko' was organised in Kumasi, the second largest city of Ghana, on 25 May 1995.