ABSTRACT

The conceptual leap from membrane or biochemical mechanisms to neural functions is, however, a substantial one. It is equally as wide as that between neural net functions and behavior. At the outset of this discussion I must acknowledge that these conceptual gaps have not yet been bridged by anything even faintly resembling a convincing empirical data base or a comprehensive theoretical model. There is, as yet, no more adequate or generally accepted answer to the question of what biochemical and membrane mechanisms account for neuronal plasticity than there is to the question of how neuronal plasticity and the resulting changes in the network state account for learning.