ABSTRACT
This chapter describes trade name, classification, approved indications for psychological disorders, available dosage forms, storage, and compatibility, usual dosage and administration, relative contraindications, and clinically significant drug interactions of Clorazepate. Long-term clorazepate pharmacotherapy, or regular personal use, may lead to addiction and habituation. Clorazepate has the chemical characteristics of the benzodiazepines and produces similar Central Nervous System (CNS) depressant actions. A clorazepate withdrawal syndrome similar to the alcohol withdrawal syndrome has occurred following the abrupt discontinuation of long-term high-dosage clorazepate pharmacotherapy, or regular personal use. Concurrent clorazepate pharmacotherapy with opiate analgesics, other sedative-hypnotics, or other drugs that cause CNS depression may result in additive CNS depression. Signs and symptoms of clorazepate overdosage correspond to varying degrees of CNS depression, ranging from slight sedation to coma. Clorazepate overdosage requires emergency symptomatic medical support of body systems with attention to increasing clorazepate elimination.
