ABSTRACT
Procyclidine overdosage should be treated as a medical emergency requiring symptomatic medical support of body systems with attention to increasing procyclidine elimination. Concurrent alcohol use may increase the CNS depressant action of procyclidine. Advise patients to avoid, or limit, their use of alcohol while receiving procyclidine pharmacotherapy. Signs and symptoms of procyclidine overdosage include convulsions, drowsiness, dry mouth, excitement, giddiness, mental confusion, nausea, and vomiting. Ingestion of each dose of procyclidine after meals or with food may minimize associated epigastric irritation. Usually, procyclidine pharmacotherapy is of greater efficacy for the symptomatic management of rigidity rather than tremor. Procyclidine is chemically related to trihexyphenidyl and elicits an atropine-like antispasmodic effect on smooth muscle. Procyclidine pharmacotherapy may significantly aggravate or cause urinary retention as a direct result of its antimuscarinic activity. Procyclidine pharmacotherapy may aggravate or cause several mental disorders.
