The term “ecosystems” was developed by Arthur Tansley in the 1930s to describe a localized community of living organisms interacting with each other. A key characteristic of the transition to business ecosystems is the blurring of boundaries between stakeholders, technologies, and roles. These business ecosystems create new opportunities and value for participating stakeholders – they are designed to: make money/create value; delight customers; address social challenges; and create, service, and deploy communities. The energy–water–food ecosystem is essentially leveraging the collective knowledge and experience of businesses, government and civil society. The approach uses water as a lens, the denominator in the equation so to speak, in conducting hydro-economic analyses across the economy and compared to the government’s own growth and development plans. A hydro-economic analysis across the Nexus of food, water, and energy security has proven to be a transformative basis for government action and policy changes.